The U.S. GRADE Network is an entity of the GRADE working group. The U.S. GRADE Network mission is to conduct both basic and advanced GRADE workshops to disseminate best practices in guideline development as well as train GRADE methodologists.

The U.S. GRADE Network serves as the nucleus for enhanced collaboration with other US-based institutions such as the Agency for Healthcare Research and Quality (AHRQ) supported Evidence-Based Practice Centers (EPCs), the Centers for Disease Control and Prevention (CDC), and the US Cochrane Center and branches, among others.